The aim of present study was to formulate and evaluate the mouth dissolving tablets of flurbiprofen using various superdisintegrants for rapid disintegration, to improve patient compliance and to obtain disintegration time <30 sec. Effect of varying concentration of various superdisintegrants such as crosspovidone, croscarmellose sodium, sodium starch glycolate (SSG) on disintegration time and wetting time was studied. DSC study showed that, there is no drug excipients interaction. Tablets were prepared using direct compression method and were evaluated for hardness, friability, drug content, In vitro disintegration time, wetting time, and In vitro drug release. The results of disintegrating time and wetting time of tablets prepared using croscarmellose sodium and SSG were significantly superior compared to superdisintegrants. The optimization of formulation was done by using 32 full factorial designs. A 32 full factorial design was applied to systematically optimize the drug disintegration time, wetting time and drug release. The concentration of SSG(X1) and concentration of Croscarmellose(X2) were selected as independent variables.