On a moonless Alabama night, the house is cold and eerily quiet. When the front door is violently forced open, heavy footsteps go unheard. The intruder enters the room where Lizzie and her two children lie huddled together in a coma-like sleep. Awakened by her baby's frantic cries, Lizzie strains through the darkness to see a shadowy figure clutching her child. A harrowing assault ensues, leaving tragedy in its wake. Meanwhile, at her home in South Carolina, Addie is abruptly awakened by a vision of her estranged twin in imminent danger. She rushes to her aid. Upon arrival, she's confronted with a horrific scene. With no time to consider the consequences, she makes rash decisions to safeguard her family from the aftermath. In the safety of Addie's home, the sisters must not only confront their past but also the looming threats closing in on them. As they are thrust deeper into mounting conflicts, the sisters join forces to outwit adversaries who threaten to expose their secrets hidden deep in the twisted vine.